Abdominal rubber drain piece aggravates intra‐abdominal sepsis in the rat

. Biomaterials in the peritoneal cavity disrupt the physiology of the host and may cause bacterial translocation. The current study was performed to determine whether biomaterials exacerbate intraabdominal infections. Adult male rats were divided into four groups: group 1, celiotomy + intraperitoneal (i.p.) saline; group 2, celiotomy + i.p. Escherichia coli (3 times 108 cfu); group 3, i.p. rubber + i.p. saline; and group 4, i.p. rubber + i.p. E. coli(3 times 108 cfu). Twelve h after the challenge, enteric bacterial translocation, bacterial population levels in the cecum and serum levels of IL-6 and TNF were measured. Bacterial translocation to mesenteric lymph nodes and the liver was observed in animals from groups 2 and 3, but significantly increased in group 4 with a concomitant elevation of serum levels of TNF and IL-6, as compared with group 1. Histological examination revealed a more pronounced inflammatory reaction in the peritoneum and distal ileum in group 4 than in groups 2 and 3. These results suggest that the presence of rubbers in the peritoneal cavity aggravates intraabdominal sepsis.