Constitutional H19 Hypermethylation in a Patient With Isolated Cardiac Tumor

Beckwith–Wiedemann syndrome (BWS) is clinically and molecularly very heterogenous. Molecular findings characteristic of BWS have been reported in individuals with no or few associated features. We report on a child with isolated cardiac tumor and a constitutional H19 hypermethylation with none of the features of BWS. © 2008 Wiley-Liss, Inc.