3-Amino- and 5-aminopyrazoles with anticonvulsant activity

New 3-amino- and 5-aminopyrazoles were synthesised. 3-Aminopyrazoles exert a strong anticonvulsant effect. 4-Chlorophenyl-3-( morpholin-4-yl)-1H-pyrazole 2 distinctively blocks sodium channels and is strongly effective in the Maximal Electroshock Seizure (MES) test.