Clinical and Epidemiological Characteristics of Multiple Myeloma (MM): Comparison Between Hematopoietic Stem Cell Transplantation (HSCT) and Conventional Chemotherapy,

Abstract 4166 INTRODUCTION: The purpose of this epidemiological retrospective study was to describe the natural history, clinical features, treatment and outcome of a wide population of multiple myeloma (MM) patients during a 2-year period. MATERIALS AND METHODS: Data from 338 patients9 files from 37 Spanish centers were collected during 2009. Included patients had ISS stage II-III MM and started first line treatment according to daily practice between Sep903-Aug905. Response rate (RR) following IMWG criteria and survival from diagnosis are analyzed in patients either with or without hematopoietic stem cell transplantation (HSCT). Because immunotechniques were not always available back then, stringent complete response is categorized as complete response (CR) and very good partial response as partial response (PR). Statistics on survival are calculated using univarite Cox analyses, and Chi-square and Fisher exact test are used for categorical results; valid percentages are presented. RESULTS: Patients had a median of 66 (21–88) years of age at the time of diagnosis, good to moderate ECOG performance status (0–1, 50%; 2, 25%), and 1:1 ratio male:female. Besides staging II (42%) or III (58%) MM, most (95%) exhibited secretory disease, and bone lesions were common (73%). Anemia (hemoglobin CONCLUSION: Results of this Spanish nation-wide epidemiological study confirmed previous findings in other countries (Kyle, 2003; Conte, 2007). As expected, efficacy varied depending on patient9s characteristics and treatment. No safety issues were noted. Survival rate was enhanced by HSCT. Further reports on the outcomes sorted by treatment regimen, as well as potential prognostic factors, will be presented. Disclosures: Lopez: Celgene: Employment. Baquero: Celgene: Employment.