Effect of synthetic prostaglandin E1 on the cardiac blood supply and systemic hemodynamics in acute myocardial ischemia

: The effect of a native synthetic prostaglandin E1 on the blood supply and basic parameters of hemodynamics in acute myocardial ischemia induced by coronary artery occlusion was studied. It was found that the preparation in doses of 5 and 10 mg/kg increases the general and collateral coronary circulation by redistributing it into the endocardium of myocardial ischemic lesion. PGE1 increased the systolic discharge and the minute volume of the heart, enhanced the contractile myocardium activity. With an increase of the preparation dose its positive effect was not enhanced.