Actividad antimicrobiana de los extractos polares de tres especies de solanum: s. hypomalocophyllum bitter, s. mamosum l y s.sycophanta dunal et dc de Venezuela

In this study antibacterial activity of three species of Solanum, collected in the Venezuelan Andes is reported. Antibacterial activity was measured by the diffusion in agar method using bacteria and yeasts of international reference for comparison. Hydroalcoholic extracts of roots, stems and leaves of S. mamosum L. showed respectively a CIM of 420, 260 and 120 mg/ml of activity against Staphylococcus aureous (ATCC 25923). If S. aureus was resistant to meticilina SARM 525 only stems and and leaves were active and showed CIM of 180 and 90 mg/ml respectively. A crude butanolic extract of the green berries (MDA) of S. hypomalacophyllum Bitter showed activity against SARM 525, with CIM of 30 mg/ml. On the other hand desacetoxy-solafi lidine (3) was active with a CIM of 20 mg/ml. Regarding antifungic activity MDA and compound 3 presented activity against Candida crusei (ATCC 6258), but MDA (CIM 25mg/ml) performed better than compound 3, which means that activity of MDA is associated to sinergism. Solanum sycophanta extracts were not active.