Evaluation of graft-versus-host disease based on measurement of HLA levels in the plasma of allogeneic bone marrow recipients

HLA levels were estimated in the plasma of allogeneic bone marrow recipients with and without graft-versus-host disease (GVHD). It was found that the level of plasma-soluble HLA is elevated in recipients with developing acute GVHD and that a rise in these antigens coincides with the onset of clinically manifest GVHD.