Clinicopathological significance of Notch1 expression in cervical cancer patients: a meta-analysis

Aim: Notch1 expression remains incompatible and contradictory with previous findings on cervical cancer. The purpose of this study is to evaluate the association between Notch1 and cervical cancer. Methods: Available studies were searched from diverse databases and Review Managers 5.3 software was used to perform analysis. Results: A total of 798 samples were included in this meta-analysis. The Notch1 expression in cancer tissues was higher than that in precancer (p = 0.0003) and normal tissues (p < 0.02). However, the difference of Notch1 expression between cancer cases and precancer cases has no statistical significance (p = 0.35). Moreover, lymph node metastasis (p = 0.02) was associated with higher Notch1 expression in cervical cancer. Conclusion: Notch1 over-expression indicated aggressive biological behaviors.