Facet-dependent Biodegradable Mn 3 O 4 Nanoparticles for Ameliorating Parkinson's Disease

Parkinson's disease (PD) is a common neurodegeneration disease. Unfortunately, there are no effective measures to prevent or inhibit this disease. In this study, we prepared biodegradable Mn3 O4 nanoparticles (NPs) in different shapes and enclosed them by {100}, {200} and {103} facets that exhibited facet-dependent protection against neurotoxicity induced by oxidative damage in a cell model of PD. Notably, Mn3 O4 nanorods enclosed by {103} facets exhibited high levels of enzyme-like activity to eliminate reactive oxygen species (ROS) in vitro. We also determined that the uptake pathway of Mn3 O4 NPs into MN9D cells was mediated by caveolin. Our data demonstrated that Mn3 O4 nanorods could be taken up by cells effectively and conferred excellent levels of neuroprotection while the biodegradation of Mn3 O4 NPs in vivo was confirmed by photoacoustic (PA) image of Mn3 O4 NPs in brain at 60 days. Furthermore, the oxygen scavenging effect created by Mn3 O4 nanorods was successfully applied to a mouse model of PD; the amount of α-synuclein (α-syn) in the cerebrospinal fluid of PD mice was reduced by 61.2% in two weeks, thus demonstrating the potential application of facet-directed Mn3 O4 NPs for the clinical therapy of neurodegenerative disease. This article is protected by copyright. All rights reserved.