miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

Hemanth N. Banavath,Barbara Roman,Nathan Mackowski,Debjit Biswas,Junaid Afzal,Yohei Nomura,Soroosh Solhjoo,Brian O’Rourke,Mark J. Kohr,Elizabeth Murphy,Charles Steenbergen,Samarjit Das

miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

2019

Hemanth N. Banavath
Barbara Roman
Nathan Mackowski
Debjit Biswas
Junaid Afzal
Yohei Nomura
Soroosh Solhjoo
Brian O’Rourke
Mark J. Kohr
Elizabeth Murphy
Charles Steenbergen
Samarjit Das

Background Translocation of miR‐181c into cardiac mitochondria downregulates the mitochondrial gene, mt‐COX1. miR‐181c/d−/− hearts experience less oxidative stress during ischemia/reperfusion (I/R)...

Keywords:

Ischemia
Cardiology
Internal medicine
Mitochondrial calcium uptake
Diabetes mellitus
Mitochondrial DNA
Mitochondrion
Endocrinology
Oxidative stress
Chromosomal translocation
Medicine
Heart failure

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