Reduction of radiation lethality in dogs by chemical mixture.

Abstract : A total of 68 small dogs were individually exposed to supra-lethal doses of 600 r, 1.8 x LD(100), of acute whole-body radiation from a cobalt 60 source. The administration of 4 to 5 mg/kg of para-aminopropiophenone (PAPP) intravenously 30 minutes before, and 225 mg (total dose) of S, beta- aminoethylisothiuronium (AET) plus 32.5 mg (total dose) of serotonin intraperitoneally 10 to 15 min before irradiation provided 58% survival, whereas the administration of PAPP alone protected only 13%. By supplementing this pre- irradiation chemical treatment with postirradiation supportive therapy consisting of antibiotics, vitamins, parenteral fluids, and whole-blood transfusions, the survival of the PAPP treated dogs was increased to 63%, while the survival of the dogs receiving the chemical mixture was increased to 8 / AD- 328 454Div. 22/1 U (TISTW/RD) Naval Ordnance Test Station, China Lake, Calif. THE THERMAL DECOMPOSITION CHARACTERISTICS OF EXPLOSIVES .. RR ee pp tt .. MM