Comparison of Acute Thrombogenicity and Albumin Adsorption in Three Different Durable Polymer Coronary Drug-Eluting Stents.

AIMS: This study sought to compare thromboresistance and albumin binding capacity of different durable polymer DESs using dedicated preclinical and in vitro models. METHODS AND RESULTS: In an ex vivo swine arterio-venous shunt model, fluoropolymer everolimus-eluting stent (FP-EES) (n=14) was compared with two durable polymer DES (BioLinx polymer coated zotarolimus-eluting stent (BL-ZES)(n=9) and a CarboSil(R) elastomer polymer coated ridaforolimus-eluting stent (EP-RES)(n=6)), and bare metal stents (BMS)(n=10). Stents underwent immunostaining using a cocktail of anti-platelet antibodies and a marker for inflammation and then were evaluated by confocal microscopy (CM). Albumin retention was assessed by using a flow loop model with labeled human serum albumin [FP-EES(n=8), BL-ZES(n=4), EP-RES(n=4), and BMS(n=7)] and scanned by CM. The area of platelet adherence (normalized to total stent surface area) was lower in order of FP-EES (9.8%), BL-ZES (32.7%), EP-RES (87.6%) and BMS (202.0%) and inflammatory cell densities was least for FP-EES

Keywords:

• Stent
• Human serum albumin
• Urology
• Platelet
• Albumin
• Ex vivo
• Fluoropolymer
• Medicine
• Cardiology
• Polymer
• Thrombogenicity
• Internal medicine
• Drug

• Correction
• Source
• Cite
• Save
• Machine Reading By IdeaReader