Abstract 17596: Preliminary Results from EUglycemia for Renal Impairement Prevention After Contrast-medium Exposure (EURIPE) Randomized Study

Introduction: Up-to-date, the gold standard for Contrast Induced-Acute Kidney Injury (CI-AKI) prevention is hydration with isotonic saline solution (ISS), whereas, the role of several protective agents, such as N-Acetyl-Cysteine (NAC) has been largely discussed, with conflicting results. Poor glycemic control has also been associated with increased incidence of CI-AKI. Hypothesis: Thus, we aimed to evaluate the efficacy of glucose-insulin-potassium (GIK) and NAC, in addition to ISS, for the prevention of renal contrast damage, assessed by serum Creatinine (sCr) and plasmatic Neutrophil Gelatinase-Associated Lipocalin (pNGAL) elevation, in patients undergoing percutaneous coronary intervention (PCI). Methods: To date, 102 diabetic and/or with chronic renal failure patients were randomized to 3 different protocols: ISS-GIK-NAC (group 1), ISS-GIK (group 2), ISS (group 3). ISS and GIK infusion started 12 hours before PCI and maintained up to 12 hours after the procedure. NAC was given before PCI (2400 mg). We...