F-FDG PET/CT study on functional changes in the cortex of the frontal and parietal lobes in Parkinson's disease.

Objective To study the functional changes of the frontal and parietal cortex in cat models of Parkinson′s disease(PD).Methods Healthy male cats were injected MPTP to establish animal models of dipl-PD.The four model groups comprised by 2,5,8 and 11 days after the first drug pour.After observation of biological behavior and HE stain,model groups were injected with 18 F-FDG i.v.Then,we determined the region of interest(ROI) by observing 18F-FDG intensity and carried out a semi-quantitative analysis after detecting the standard absorption value(SUV) in this area.Results Compared with the control group,the 18 F-FDG intensity and SUV were normal in both sides of the frontal and parietal cortex in the PD models on the 2nd day after the first injection(P0.05),and was significantly reduced on the 5th day in both sides of the frontal cortex(P0.05),but remained normal in both sides of the parietal cortex.The value of both sides of the frontal cortex on the 8th day was lower than that on the 5th day,while both sides of the parietal cortex significantly increased compared with that on the 5th day(P0.05).On the 11th day,the value ofboth sides of the frontal cortex was consistent with that on the 8th day,while the value of both sides of the parietal cortex returned to the normal level on the 8th day.There was no difference between the left and right sides of the frontal and parietal cortex of each group(P0.05).Conclusions Reduction of glucose metabolism in the frontal cortex of PD suggests that there is a functional disorder in this area,aggravating with time and being stable at some degree,while the increase of glucose metabolism in the parietal cortex of PD suggests that there is a transient functional accentuation in this area as a compensation for dysfunction of the frontal cortex.