Two Co(II) coordination polymers: magnetic properties and prevention activity on hypertension during pregnancy by regulating the VEGF in vascular endothelial cells

Two new Co(II) coordination polymers, namely, [Co(L)(bpe)(H2O)]n·[Co0.5(bpe)0.5(H2O)2]n·nH2O (1) and [Co2(L)(bpe)(μ3-OH)(H2O)]n·3nH2O (2) have been prepared via utilizing the flexible ligands of 1,2-bis(4-pyridyl)ethane (bpe) and 5-(3-carboxybenzyloxy)-isophthalic acid (H3L) under various conditions. The two compounds’ magnetic properties reveal that between the consecutive metal ions, there exists the antiferromagnetic coupling. Their application values on the hypertension during pregnancy prevention were assessed and their specific mechanism was also studied in meantime. Firstly, the VEGF (vascular endothelial growth factor) relative expression in vascular endothelial cells was determined via the real time reverse transcription-polymerase. In addition to this, in vascular endothelial cells, the inflammatory response was detected through ELISA (enzyme linked immunosorbent assay) detection by measuring the inflammatory cytokines releasing.