ORAL BIOAVAILABILITY AND PHARMACOKINETICS OF BAQUILOPRIM IN DWARF GOATS

Abstract The pharmacokinetics of baquiloprim at a dose of 8 mg kg --l bodyweight were determined after its intravenous and intra-ruminal administration to seven healthy female dwarf goats. After intravenous injection, the plasma elimination curve showed a rapid distribution phase (mean [ sd ] t 1 2α 0·89 [0·4] hours). The mean volume of distribution at steady-state (V dss ) was 14·1 (2·7) litres kg −1 bodyweight. The mean elimination half-life ( t 1 2β ) was 14·0 (2·3) hours. After intra-ruminal administration its maximum concentration in plasma (C max ) was 0·09 (0·01 μg ml −1 and this maximum was not reached until approximately 35 hours after administration. The systemic oral bioavailability, calculated up to 48 hours after dosing, was 33·7 (7·1) per cent. Owing to a prolonged absorption phase, the data from only four of the goats fitted reasonably to a compartmental model.