Synthesis of 3′‐Deuterated Pyrimidine Nucleosides via Stereoselective Reduction of a Protected 3‐Oxoribose.
1998
Abstract Thymidine ( 2 ) and 5-methyl-2′- O -( t -butyldimethylsilyl)uridine ( 3 ) deuterated at the C3′-position were prepared with complete stereocontrol via NaB 2 H 4 reduction of a 3-oxoribose derivative ( 5 ). Utilization of benzyl protecting groups in the deuterated glycosidation substrate facilitates the synthesis of ribonucleosides and 2′-deoxyribonucleosides with minimal protecting group manipulations.
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