R462Q Mutation in Prostate Cancer Specimens

Results: The present study findings showed that RR, RQ and QQ genotypes compromised 82, 14, and 4% of the cancerous samples and 87, 13 and 0 % of the non-cancerous samples, respectively. Conclusions: We did not find any association between the RNASEL Arg462Gln polymorphism and prostate cancer. Based on these results the RNASEL Gln/Gln genotype does not play an important role in the etiology of sporadic prostate cancer, in the general population. However, additional studies with bigger sample sizes are needed to more clearly explain the role of RNASEL mutations in hereditary prostate cancer.