Design, synthesis and structure-activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists.

Abstract A series of 5-alkylaminolquinolines was designed and synthesized as potential novel CRF 1 receptor antagonists. The structure–activity relationships (SARs) of the substituents on each position (R 2 , R 3 , R 5 and R 5′ ) were investigated.