The synthesis of substituted fluorenes as novel non-imidazole histamine H3 inhibitors

Pauline C. Ting,Joe F. Lee,Margaret M. Albanese,Wing C. Tom,Daniel M. Solomon,Robert G. Aslanian,Neng-Yang Shih,Robert E. West

The synthesis of substituted fluorenes as novel non-imidazole histamine H3 inhibitors

2002

Pauline C. Ting
Joe F. Lee
Margaret M. Albanese
Wing C. Tom
Daniel M. Solomon
Robert G. Aslanian
Neng-Yang Shih
Robert E. West

Abstract A novel non-imidazole fluorene oxime 1a has been identified as a histamine H 3 inhibitor, and its structure–activity relationship has been evaluated.

Keywords:

Histamine
Organic chemistry
Chemical synthesis
Fluorene
Biochemistry
Structure–activity relationship
Imidazole
Oxime
Chemistry
Stereochemistry
Antagonist
In vitro
tertiary amine

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