A Self-healing Tumor on the Upper Lip

REPORT OF A CASE A 49-year-old woman complained about a single, painful tumor located on her upper lip. It was firm, red, and ulcerated. The tumor had grown rapidly to 2 cm in diameter in 3 weeks ( Figure 1 ). No other abnormality was found on physical examination. Lymphadenopathy was absent. No significant laboratory findings were present. A biopsy specimen was obtained for histopathologic examination ( Figure 2 and Figure 3 ), and the tumor regressed 1 month later ( Figure 4 ). Immunoperoxidase staining with CD30 antibodies is shown in Figure 5. What is your diagnosis? DIAGNOSIS: Primary cutaneous CD30+ large cell anaplastic T-cell lymphoma (LCAL). HISTOPATHOLOGIC FINDINGS The hematoxylin-eosin—stained sections showed an ulcerated tumor composed of a dense, nonepidermotropic, lymphoid infiltrate located in all levels of the dermis (Figure 3). The infiltrate was composed mainly of large cells with abundant cytoplasm and pleomorphic nucleus, with clear chromatin and 1 or more prominent nucleoli.