DOSE-RESPONSE CURVE OF SOMINA (HERBAL PREPARATION): A STUDY ON FROG HEART

Dose response relation is important with respect to pharmacological efficacy of drug substances and must be known for herbal preparation. Herbal preparations Somina (Hamdard Patent), having five ingredients is not yet screened for its dose response relation. In the present study Somina is used for the determination of dose response on exposed Frog’s heart preparation. U’s shape dose response curve was obtained which shows maximum response at 20mg/ml while it was found to reduce at low and higher doses. The dose response curve is discussed on the basis of properties of ingredients available in this herbal preparation.