Distribution of 31 endocrine-disrupting compounds in the Taihu Lake and application of the fish plasma model

The successful application of Fish plasma model (FPM) will greatly simplify the risk assessment of drugs. At present, the FPM has been applied to the risk assessment of several human drugs with high hydrophobicity. However, its applicability to a wide variety of compounds needs to be tested. Field work about distribution characteristics of endocrine disrupting compounds (EDCs) in water and in fish plasma plays a key role in promoting the successful application of FPM. However, there are few reports on the distribution of EDCs in fish, especially in wild fish plasma. The distribution of 31 EDCs, including seven estrogens, eight androgens, six progesterones, five glucocorticoids, and five industrial compounds, in water and plasma of five categories of wild fishes in Taihu Lake was studied and the typical FPM was tested by the field data. The detected concentration of most compounds is relatively low (  3.87) in fish plasma. Although the present FPM is barely satisfactory, it is still promising for predicting the accumulation of EDCs in fish plasma and for further environmental risk assessment.