THE PHYSIOLOGICAL DISPOSITION OF CHLOROTHIAZIDE (DIURIL) IN THE DOG

Chlorothiazide is excreted rapidly and completely in the urine following its intravenous administration to dogs. Renal clearance studies show that chlorothiazide is secreted by the renal tubules; the tubular secretory component can be inhibited by probenecid. In nephrectomized dogs, plasma levels of a single intravenous dose of chlorothiazide fall as a result of rapid elimination in the bile, as much as 41% of a dose being excreted in the bile in 4 hours. Some 30 to 60% of a single oral dose of chlorothiazide is excreted in the urine. No accumulation of drug could be demonstrated in erythrocytes or tissues following C 14 -labeled chlorothiazide.