The action of scopolamine on retrieval and memory storage in rats evaluated in the staircase maze

Rats were trained to run on a staircase stopping on the 3rd, 6th, 9th, and 12th steps (correct responses). Stopping on any other step was considered an error. The acute administration of scopolamine (1.5 mg/kg) 20 min before the trial caused a reduction of the correct responses. An interruption of the daily training for 20 days caused, in the controls, a 24% reduction of correct responses. A chronic administration of scopolamine, at doses over 10 mg/kg in the first 15 days of the no-training period, nullified the behavioral deterioration observed in the controls. The interpretation of these results is that scopolamine damages the retrieval process and blocks the spontaneous decay of memory, as was observed in the controls after 20 days of interruption of the daily training.