Primary results of the phase II CheckRad-CD8 trial: First-line treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) with double checkpoint blockade and radiotherapy dependent on intratumoral CD8+ T-cell infiltration.

Markus Hecht,Markus Eckstein,Sandra Rutzner,Jens von der Grün,Thomas Illmer,Gunther Klautke,Simon Laban,Matthias G. Hautmann,Thomas Brunner,Bálint Tamaskovics,Axel Hinke,Benjamin Frey,Sabine Semrau,Arndt Hartmann,Panagiotis Balermpas,Wilfried Budach,Udo S. Gaipl,Heinrich Iro,Antoniu-Oreste Gostian,Rainer Fietkau

Primary results of the phase II CheckRad-CD8 trial: First-line treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) with double checkpoint blockade and radiotherapy dependent on intratumoral CD8+ T-cell infiltration.

2021

6007Background: Inhibition of the PD-1/PD-L1 pathway is efficient in recurrent/metastatic HNSCC. Targeting the immune checkpoint CTLA-4 may be synergistic to radiotherapy. This trial studies feasib...

Keywords:

Medicine
locally advanced
Cytotoxic T cell
Immune checkpoint
CD8
Cancer research
Radiation therapy
Blockade
infiltration
Head and neck squamous-cell carcinoma

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