ANALYSIS OF THERAPEUTIC EFFECT OF TELBIVUDINE ON SEVERE CHRONIC HEPATITIS B

Objective To investigate the clinical effect of telbivudine therapy on severe chronic hepatitis B. Methods Twenty four patients with severe chronic hepatitis B were randomly divided into two groups.Each group has twelve patients and was given basic comprehensive treatment.Telbivudine group was given the same drugs plus telbivudine(600 mg/d) for 12 w.The major clinical outcomes and hepatic function of two groups were evaluated after twelve weeks of treatment. Results The major clinical symptoms,hepatic function and PTA improved in both group than before treatment.There was obviously decreasing in TBIL、ALT、AST、PTA and the level of HBV-DNA in telbivudine group after 12 weeks,the index of telbivudine group showed a significant difference from the control group(p0.05).The serum HBV-DNA level of telbivudine group after treatment comparing with that of control group had significant statistic difference(p=0.015). Conclusion Telbivudine can effectively inhibit HBV replication and telbivudine combined with basic comprehensive treatment can significantly improve the chronic severe hepatitis B patients with clinical symptoms.