Desloratadine nitric oxide donor, and preparation method and application thereof

The invention belongs to the technical field of medicine, and discloses a desloratadine nitric oxide donor with novel structure shown as a formula I and pharmaceutically acceptable salts thereof, wherein X is carbonyl or sulfonyl, n equals to 0, 1 or 2, and R is hydrogen and C1-C4 alkyl. The invention also relates to a preparation of the compound, and also discloses a pharmaceutical composition using the compound or the pharmaceutically acceptable salt thereof as an active ingredient, and application thereof as antitumor drug, especially application thereof to preparation of drugs for the treatment of breast cancer, lung cancer and stomach cancer.