The TYROL Study SCLC Project: retrospective analysis of clinical features and therapeutic outcome in 484 small cell lung cancer patients diagnosed 1991 – 2011

Conclusion There are patients with a chance of long term survival, even cure. We are working on the establishment of diagnostic and therapeutic algorithms for an optimized management in this unfavourable disease. Table 1: Patients characteristics at primary diagnosis Results – Patients Characteristics Of 484 patients, 326 (67%) were male, further characteristics, see Table 1. Symptoms at initial diagnosis: hemoptysis 44/293 (15%), cough 165/299 (55%); dyspnoea 153/302 (51%); tumor pain 135/305 (44%); neurologic symptoms (incl. paraneoplasia) 69/314 (22%); hyponatremia (≤130 mmol/l)/SIADH 47/339 (14%); prior/present other malignancy 86/436 (20%). Results – Response 27 patients (6%) did not receive any treatment. In the 411 evaluable patients with palliative therapy, overall response was 57% (Table 2); however, best response (at any time during treatment) was 78%. ORR was dependent on patients characteristics (Table 2).