INVESTIGATING ANTIOXIDANT EFFECT OF CINNAMON EXTRACT ON ELIMINATION OF TOXICITY OF GELOFEN DRUG IN KIDNEY TISSUE OF FEMALE RATS

Gelofen is such as anti-inflammatory drugs that through inhibit prostaglandins and inhibiting cyclooxygenase enzyme, preventing conversion of arachidonic acid to the intermediate Endo peroxides and it has numerous effects on various tissues of the body. Cinnamon bark has many Therapeutic properties, so that its use strengthens the heart, stomach and intestines and improving kidney activities. So finding a suitable antioxidant in order to reducing side effects of gelofen drug that is as common drug to reduce menstrual cramps is essential. 49 female Wistar rats were randomly divided into 7 groups. The first group (control group) did not receive any medication. The second group (sham group) was injected only normal saline. Experimental group 1 was given only gelofen Drug (400 mg / kg) intraperitoneally. Experimental group 2 received only cinnamon extract (50 mg/kg) and experimental group 3 received cinnamon extract with dose of (200 mg/kg). Experimental groups 3 and 4, in addition gelofen Drug (400 mg / kg) received cinnamon extract with doses of (50 mg / kg) and (200 mg / kg). At the end of 21 days, rats were anesthetized and kidney tissue were removed and it was sent to laboratory for histopathological studies. Results revealed that in Diameter of Bowman's capsule in G100 group has significant decrease compared to the control group. Cortex diameter in G100 and GCi 50 groups has significant decrease compared to the control group. Medullary diameter in G100 group showed significant decrease compared to control group. Distance curved pipe diameter in G100 and GCi50 groups has significant decrease compared to the control group. Close curved pipe diameter in experimental group GCi200 has significant increase compared to control group (P<0.05). In conclusions, Cinnamon extract has antioxidant properties, thereby it reduces nephrotoxicity due to gelofen consumption.