Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization

Kidney epithelial cells grown in 3D culture form polarized cysts in which basal membranes surround a lumen. Peng et al. show that the p110δ subunit of phosphoinositide 3-kinase contributes to the formation of these structures by influencing focal adhesion at the basal membrane.