One-Pot Highly Efficient Synthesis of Substituted Pyrroles and N-Bridgehead Pyrroles by Zinc-Catalyzed Multicomponent Reaction.

A convenient zinc(II) chloride-catalyzed regioselective propargylation—amination—cycloisomerization process is developed for the synthesis of substituted pyrrole derivatives from propargylic acetates, enoxysilanes and primary amines.