Enhancement of GST-P-positive liver cell foci development by nivalenol, a trichothecene mycotoxin

In order to elucidate whether T-2 toxin (T-2) and nivalenol (NIV), the naturally occurring trichothecene mycotoxins in food and feed, are carcinogenic or possess an ability to modulate aflatoxin B 1 (AFB 1 )-induced hepatocarcinogenicity, a medium-term liver bioassay was carried out. F344 male rats were gien a single i.p. injection of diethylnitrosamine (DEN, 200 mg/kg), and then fed the test trichothecenes in diet (2 and 5 p.p.m. T-2 or 6 p.p.m. NIV) for 6 weeks beginning 2 weeks after the injection