Neurotoxic effect of povidone–iodine on the rat spine using a laminectomy–durotomy model

Objective The efficacy and safety of povidone–iodine in wound dressing and irrigation of some operative cavities were established by many in vitro and in vivo experimental reports and clinical series. However, its use in defective tissue in neural structures has not been confirmed yet. The aim of the present study was to histopathologically investigate its effect on neural tissues when applied on the upper side of defective dura.