Effect of peroxisome proliferator-activated receptor-γactivator 15d-PGJ2 on hypertrophic scar in rabbit ear

Objective To investigate the effect of 15d-PGJ2on the expression of CD34,TGF-β1andα-SMA on hypertrophic scar in rabbit ear and the possibility of hypertrophic scar treated by 15d-PGJ2.Methods 9New Zealand white rabbits were used to establish a hypertrophic scar model on the rabbit ear.The wounds were established as follows:2cm×2cm wounds with total skin loses on the ventral side,2wounds for each ear,totally 36 wounds.The wounds were randomly divided into the 15d-PGJ2treatment group and normal saline control group.10μL 15d-PGJ2or normal saline was injected into the ear scar once a day for 7days.At 3,6and 17days after the injection.The expression of CD34and TGF-β1was detected by immunohistochemical method.Results Excessive dermal scars on rabbit ear that were similar to human hypertrophic scar appeared in the two groups.Compared with the NS-treated scar group,the 15d-PGJ2-treated scars appeared to be smaller,softer,flatter and lighter in color.The expression of CD34and TGF-β1in the 15d-PGJ2group was significantly decreased as compared with that in the control group at different time points(P0.05).Conclusion 15dPGJ2,the ligand of PPAR-γ,can reduce the expression of CD34and TGF-β1of hypertrophic scar in the rabbit ear and plays an important role in the prevention and treatment of hypertrophic scar.