[Application value of low-dose computed tomography for the screening of lung cancer in high-risk group].

Objective To analyze the value of low-dose computed tomography(LDCT) in early screening of lung cancer in high-risk group.Methods LDCT was performed in 1551 adults over 40-years old(male 1054,female 497) for the screening of lung cancer in Examination Center of West China Hospital,Sichuan University,and the subjects were divided into high-risk group and non-high-risk group according to risk factors of lung caner.The detection rates of lung lesion and lung cancer in these two groups were carefully analyzed.Results In the people over 40-years old,the detection rate of pulmonary lesions by LDCT was 54.41%(844/1551),the detection rate of nodules was 29.4%(456/1551).Detection rate of lung cancer was 0.51%(8/1551),while it was 1.21%(7/577) in high-risk group,and 2.01%(6/298) in heavy smoker group.The difference of lung cancer detection rate was significant(P0.05).When stratified with the number of risk factors,the detection rate of lung cancer by LDCT was 0.10%(1/974) in the subjects without any high-risk factors,0.98%(5/506) in the subjects with one high-risk factor and 2.86%(2/70) in the subjects with more high-risk factors,and the differences were stastatically significant(P0.05).Conclusion LDCT can detect asymptomatic lung cancer sensitively with low radiation dose,which could be helpful for the screening of lung cancer.