Pyrrole derivatives, their preparation and their application in therapeutic

2008 
The invention relates to compounds of formula (I): wherein: - R1 represents a hydrogen atom or a (C1-C4) alkyl; - R2 represents a radical homopiperidin-1-yl, piperidin 1-yl, pyrrolidin-1-yl, azetidin-1-yl, or an amino (C1-C6) alkyl; - or R1 and R2 together with the nitrogen atom to which they are bonded, form a piperazin-1 yl or 1,4-diazepan-1-yl, homopiperidin-1-yl, piperidin-1-yl, pyrrolidin-1-yl or azetidin-1-yl; - one of the two substituents R3, R6 represents a group Y a-R9, - Y represents an oxygen atom, -S (O) n-, -OSO2-, or -N (R18) -; - a represents an alkylene group (C 1 -C 4) unsubstituted; - R9 is -OR12, -CN, -CO2H, NR12R13, -CONR12R13, -NR15COR12, -CONHNH2, -CONHOH, -CONHSO2R14, -S (O) NR14, -SO2NR12R13, -NR18SO2R14, -NR15SO2NR12R13, or a heterocycle aromatique.La present invention also relates to the preparation processes and applications Therapeut ic compounds of formula (I).
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