The effect of polyethylene glycol and butyrate on anastomotic healing in the rat colon
2006
The use of mechanical bowel
preparation is much debated. We evaluated the
effects of polyethylene glycol (PEG), with or without a
single dose of 3.0 mmol butyrate (BUT), on the bursting
pressure (BP) of an intact colon segment and a colon anastomosis
in rats. Also, histopathologic damage was studied. In rats without colectomy, the mean BP was 159.2
mmHg (SD=18.9) after PEG treatment and 116.7 mmHg
(SD=27.5) in controls (p=0.001). In rats with colectomy,
the mean BP was 90.4 mmHg (SD=45.9) in the PEG
group, 108.0 mmHg (SD=31.9) in the BUT group, and
102.7 mmHg (SD=44.7) in controls (p=0.44). No significant
differences in histopathologic scores were observed
between rats treated with PEG and controls. PEG does not interfere with anastomotic healing in rats as
measured by BP. No benefit of a single dose of butyrate
was observed.
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