Development and Implementation of an Aluminum-Promoted Phosphorylation in the Uprifosbuvir Manufacturing Route

Zhuqing Liu,Artis Klapars,Bryon Simmons,Ana Bellomo,Alexei Kalinin,Mark Weisel,Jerry Hill,Steven M. Silverman

Development and Implementation of an Aluminum-Promoted Phosphorylation in the Uprifosbuvir Manufacturing Route

2020

Zhuqing Liu
Artis Klapars
Bryon Simmons
Ana Bellomo
Alexei Kalinin
Mark Weisel
Jerry Hill
Steven M. Silverman

A novel application of the synthesis of pronucleotide (ProTide) 5′-phosphoramidate monoesters promoted by aluminum-based Lewis acids is described. In the multikilogram synthesis of uprifosbuvir (MK...

Keywords:

Dimethylaluminum chloride
Phosphorylation
Combinatorial chemistry
Lewis acids and bases
Aluminium
Chemistry
Protide

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations