Glucosa 6 fosfato deshidrogenasa: características bioquímicas y moleculares. Prevalencia de la deficiencia

Glucose-6-phosphate dehydrogenase (G6PD) is a cytoplasmic enzyme that is distributed in all cells of the organism and that catalyzes the first step in the pentose pathway in which glucose-6-phosphate (G6P) is converted to 6-fosfogluconato (6FG) and reduced NADP to NADPH, which is essential to protect erythrocytes from oxidative damage process. The G6PD deficiency is the most common erythroenzymopathy, is recessive and X-linked, with worldwide distribution and high genetic and biochemical heterogeneity. A review of biochemical aspects, structure, genetics, molecular, enzymatic defect, prevalence of disability in the world and in Venezuela, and the role of G6PD deficiency in the treatment of malaria was conducted by the increased risk of hemolysis involves the tendency to increase the total dose of primaquine in subjects malaria, particularly in regions where infection by Plasmodium vivax predominates.