A kind of preparation method of ticarcillin sodium

The invention discloses a kind of preparation method of ticarcillin sodium.This method is：In the presence of triethylamine, 3 thiophene malonic acid obtain mixed anhydride with pivaloyl chloride reaction；6 APA and double (trimethyl silicon substrate) acetamide reactions of N, O obtain 6 APA of silanization；Then 6 APA of mixed anhydride and silanization are reacted, and obtain Ticarcillin acid；Further ticarcillin sodium is obtained with sodium iso-octoate reaction.This method has that reaction condition is gentle, simple to operate, it is simple, environment-friendly to post-process, the high income of product, the advantages of purity is good.