Monte Carlo Modeling for in vivo MRS: Generating and quantifying simulations via the Windows, Linux and Android platform

Work in context of European Union TRANSACT project. We have developed a Java/JNI/C/Fortran based software application, called MonteCarlo, with which the users can carry out Monte Carlo studies in the field of \emph{in vivo} MRS. The application is supposed to be used as a tool for supporting the \emph{j}MRUI platform, being the \emph{in vivo} MRS software system of the TRANSACT European Union project. The MonteCarlo application can be launched either as a \emph{j}MRUI custom plug-in (on Windows/Linux computers) or as a standalone Android app (on mobile devices with the Android platform). Both the MonteCarlo plug-in and the Android app version were developed as a Java/JNI/C/Fortran Makefile project by using one and the same version of the Eclipse Java IDE, the main difference between the two MonteCarlo versions being the codes, required for creating the GUI. We have tested the two versions of the MonteCarlo application with a few Monte Carlo studies, which enabled us to verify specific topics of \emph{in vivo} MRS Monte Carlo modeling, such as "parametric vs semi-parametric'' estimation, checking "Maximum Likelihood'' properties and dealing with the "Bias-Variance trade-off'' problem.