Epidemiology and factors associated with overweight in adults with cystic fibrosis: an Italian multicenter experience

Overweight and obesity are progressively becoming a source of concern in cystic fibrosis (CF) care, especially in adult population and in developed countries. The main objectives of this study is to investigate the epidemiological impact of overweight in a large multicentric population of adults with CF. We performed a cross-sectional analysis of the Milano-Roma database enrolling adult CF patients and followed up from 2006 to 2016 at three major CF centers in Italy. Three groups were selected according to BMI classes: overweight group (OW) including BMI >=25 kg/m2, normal weight group (NW) including BMI 18.1 - 24.9 kg/m2 and underweight group (UW) including BMI A total of 321 patients were included. Median BMI in our cohort was 22.3 kg/m2 (20.9-24.4) with 4% UW. Patients with OW were 71 (22%). OW group were likely to be male (OR 3.212, p OW status was common in a large cohort of patients from Italy. Respiratory parameters were better in the OW group compared to the others, while blood lipid levels were higher in OW.