Modification of Automatic Synthesis of [ 18 F]Fluoromisonidazole on a GE TracerLAB Fx F-N Synthesis Module

A procedure for preparing 1-(2-hydroxy-3-[18F]fluoropropyl)-2-nitroimidazole ([18F]fluoromisonidazole, [18F]FMISO) on a commercially available GE TracerLAB Fx F-N synthesis module was developed. The product obtained meets all the requirements of the European Pharmacopoeia (8th ed.) for clinical use. Its decay-corrected radiochemical yield is 59 ± 4% (n = 5).