SYNTHESIS OF A NEW POTENT ANTI-ANGIOGENIC AGENT, 17α-ACETOXY-9α-FLUORO-6α-METHYLPROGESTERONE
1997
A new anti-angiogenic agent, 17α-acetoxy-9α-fluoro-6α-methylprogesterone (9α-fluoromedoroxyprogesterone acetate [FMPA, 9]) was synthesized in a 10-step sequence. FMPA (9) had about two orders of magnitude stronger antiangiogenic activity than medroxyprogesterone acetate (MPA), as estimated in a bioassay involving chorioallantoic membranes of growing chick embryos.
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