Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements
2007
A function is defined for ultraconserved elements (UCEs), extragenic regions of eukaryotic genomes can show high degrees of conservation across species. It is also found that when alternative splicing (mediated by splicing regulator proteins) leads to UCE incorporation into the splicing regulator protein's mRNA, the mRNA is targeted for degradation. Thus, the UCEs help promote negative feedback regulation of the splicing regulator gene expression.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
30
References
504
Citations
NaN
KQI