ТРАНСПЛАНТАЦИЯ АЛЛОГЕННОГО КОСТНОГО МОЗГА БЕЗ ПРОВЕДЕНИЯ ПРЕДТРАНСПЛАНТАЦИОННОГО КОНДИЦИОНИРОВАНИЯ С ИСПОЛЬЗОВАНИЕМ ЦИКЛОФОСФАМИДА И МЕЗЕНХИМАЛЬНЫХ СТРОМАЛЬНЫХ КЛЕТОК В КАЧЕСТВЕ ИНДУКЦИИ ТОЛЕРАНТНОСТИ

Summary. Case report of a patient developed deep neutropenia and severe infectious complications after chemotherapy is presented. Lasting aplasia after a course of chemotherapy, life-threatening infectious complications did not allow pretransplantation conditioning with standard immunosuppression because of extremely high risk of a lethal outcome. Allogenic bone marrow transplantation from a related donor was carried out. Immunosuppression was carried out only with cyclophosphamide (50 mg/kg on day 3 after trans -plantation) and mesenchymal stromal cells. Transplant healing (WBC >1 • 109/l) was diagnosed on day 19. The patient was discharged 3 months after transplantation. 12 months after bone marrow transplantation a 100% donor chimera persists. This case report is the first report about effective bone marrow transplantation without pretransplantation conditioning in a patient with acute leukemia and lasting aplasia after chemotherapy.Key words: allogenic bone marrow transplantation; cyclophosphamide; mesenchymal stromal cells; tole-rance, no conditioning.