Abstract 4397: Bioavailability of substituted quinoline, a gap junction enhancer

Breast cancer is one of the most malignant diseases that threaten the health of women all over the world, especially in western countries. It ranks the second leading cause of cancer deaths among women in the United States. Several drugs have been discovered to target different pathways of breast cancer cells; however, drug resistance and side effects have increasingly become a major concern. One of the effective methods is combinational treatment of different drugs. Loss of gap junctional intercellular communication (GJIC) is thought as one of the important hallmarks of cancer. It is believed that restoration of GJIC in cancer cells is related to reduction of tumorigenesis and increase of drug sensitivity. Gap junctions are intercellular channels connecting adjacent cells, allowing cells to transport small molecules ( Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4397. doi:10.1158/1538-7445.AM2011-4397