Abstract 603: Signatures of chemoprotection from ambient exposure to outdoor air pollution in the human serum albumin Cys34adductome

Many components of outdoor air pollution, such as benzene, are known to be carcinogenic to humans. However, due to spatial and temporal variation in air pollution, ambient measures of single pollutant exposures may be limited for generalizing across diverse settings. Covalent adducts of air pollutants with the free thiol at the Cys34 residue of human serum albumin represent biomarkers of recent air pollution exposure ( Citation Format: Joshua W. Smith, Robert N. O9Meally, Derek Ng, Thomas W. Kensler, Robert N. Cole, John D. Groopman. Signatures of chemoprotection from ambient exposure to outdoor air pollution in the human serum albumin Cys34 adductome [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 603.