Paraplegia as Manifestation of an Isolated Central Nervous System Relapse Following Allogeneic Hematopoietic Stem Cell Transplantation in a Woman with Acute Myelogenous Leukemia

To the Editor: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for patients with acute myelogenous leukemia (AML) due to the intensive conditioning chemoradiotherapy and the effect of graft-versus-leukemia (GVL). An isolated extramedullary (EM) relapse of acute leukemia (AL) is a rare occurrence observed more commonly after allo-HSCT rather than following conventional chemotherapy alone.[1] The prognosis of patients with EM relapse is less favorable than bone marrow (BM) relapse, and there are no standard therapies.